Generic name: Valsartan and Hydrochlorothiazide

Classification

Angiotensin II Antagonists

Indications

Hypertension.

Dosage

0.5-1 tab daily.

Contraindications

Pregnancy & severe hepatic impairment, biliary cirrhosis & cholestasis. Anuria, severe enal impairment. Refractory hypokalaemia, hyponatraemia, hypercalcaemia & symptomatic hyperuricaemia. Lactation.

Precautions

Na-&/or vol-depleted patients, renal artery stenosis, SLE.

Adverse Reactions

Headache, dizziness, fatigue, sinusitis, pharyngitis, upper resp tract infection, back pain, diarrhoea, viral infection, chest pain, nausea, rhinitis, dyspepsia, UTI, abdominal pain, micturition frequency, bronchitis, dyspnoea, leg pain, sprains, abnormal vision, leg cramps, impotence, insomnia, rash.

Interactions

K supplements, K-sparing diuretics, heparin, lithium, curare, other antihypertensives, NSAIDs, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G, insulin, oral antidiabetics, allopurinol, anticholinergics, cytotoxics, hydrochlorothiazide, methyldopa, cholestyramine, cyclosporin